The AP3 team prepares extracts from plant specimens collected by the AP1 team, and microbes cultured by the AP2 team, and screens them for novel therapeutic activities. The results help strengthen the efforts of the AP4 team to preserve the natural biodiversity in Indonesia.
Goals of AP3:
Evaluation of Indonesian microbial and plant extract libraries using high-throughput screens to identify therapeutic lead compounds. Targets include:
- Cancer
- Immune modulating diseases: AIDS, Alzheimer's disease, arthritis
- Metabolic detoxification
- Neurobiological disorders: depression, pain, addiction
- Parasitic diseases
Personnel:
- Len Bjeldanes, AP3 leader, Professor, UC Berkeley. http://nst.berkeley.edu/faculty/bjeldanes.html
- Johann Sohn, AP3 postdoc, UC Berkeley
- Tyler Johnson, AP3 postdoc, UC Berkeley and UC Santa Cruz
- Selena Bartlett, UC San Francisco. http://www.galloresearch.org/selena-bartlett.htm
- Carsten Nielsen, UC San Francisco
- Heddy Julistiono, LIPI Biology. http://sivitas.lipi.go.id/hedd001/
- Leonardus Kardono, LIPI Chemistry. http://web.lipi.go.id/sidik/read.php?idpkr=222-Leonardus%20Broto %20Sugeng%20Kardono&xml=detail
- Muhammad Hanafi, LIPI Chemistry.
- Michael Denison, UC Davis. http://www.envtox.ucdavis.edu/Faculty_Personal_Web_Pages/Denison.htm
- Phil Crews, UC Santa Cruz. http://www.chem.ucsc.edu/mnpr/Home.html
Major Accomplishments:
- 288 plant extracts screened
- 267 microbial extracts screened
- 21 microbial and 24 plant LC-MS libraries of lead extracts evaluated
- 4 microbial and 3 plant lead compounds (m/z ions) under investigation for their anti-tumor, anti-inflammatory or neurobiological activity